NFL 2026 weekly odds

Notes

• 16 games in Week 2 (Thu Sep 17–Mon Sep 21).

• TNF: Lions at Bills in the new Highmark Stadium opener. Highest total on the board (53.5).

• SNF: Colts at Chiefs (KC -6.5, 48.5).

• MNF: Giants at Rams (LAR -7, 48.5).

• Biggest favorite: 49ers -13.5 vs. Dolphins.

• Tightest lines: Panthers -1.5 at Atlanta; Broncos -2.5 vs. Jaguars; Texans -3 vs. Bengals.

• Lowest total: Eagles at Titans (39.5).

• Road favorites: Panthers, Eagles, Packers, Seahawks.

• No international/neutral sites this week (Rio is Week 3: Ravens vs. Cowboys).

• Projected scores: Favorite = (Total + |Spread|) / 2; Underdog = (Total − |Spread|) / 2.

• Logistic win probability: z=(∣Spread∣+0.35)/6.8z = (|Spread| + 0.35) / 6.8z=(∣Spread∣+0.35)/6.8, then round(100/(1+e−z))%\mathrm{round}(100 / (1 + e^{-z}))\%round(100/(1+e−z))%.

• ML implied probabilities are raw (vig included); sides will not sum to 100%.

• Lines move; treat these as a Sep 15 morning snapshot from ESPN + FantasyData.